Top 20 Healthcare Software Solutions in 2025

Intro | Main Trends in U.S. Healthcare Software

In 2025, U.S. healthcare industry stands at a pivotal inflection point.

According to the Deloitte US Center for Health Solutions’s 2025 Global Health Care Outlook, more than 70 % of C‑suite execs across five countries think of operational efficiency and productivity as top priorities.  That sets the stage for three inter‑connected trends shaping healthcare operations.

First, data silos are finally breaking down.

The “one‑system solves all” myth is gone. Today’s healthcare platforms must integrate: provider workflows, payer data, patient devices, national registries. Interoperability became foundational – and that’s good. The Deloitte report emphasises that only systems capable of secure, real‑time data exchange will support the efficiency, care‑quality and agility required in 2025.

Second, the model of care delivery is undergoing a hard shift.

Care is no longer confined to the hospital or clinic; it’s migrating into the home via softwares. Remote patient monitoring (RPM) devices, virtual visits, chronic‑care apps – all are becoming embedded into daily workflows. It’s a part of holistic approach to patient treatment, it helps doctors to do their job, but most importantly this shift  means new billing codes, new payer models, and new operational rhythms. In turn, it opens fresh revenue‑cycle pathways with a risk of growing backlog and RCM team burnout. Execs should be aware of this change.

Third, artificial intelligence is finally gaining real traction in revenue‑cycle management (RCM).

Agentic AI platforms are capable of handling today eligibility checks, prior authorizations, and denial resolutions. They’re taking over repetitive back‑office workflows. The challenge now is scaling from 5‑10 % automation to 50 %+ in organizations large and small.

In short, here’s our explanatory equation:

2025  in Healthcare = intelligent automation (AI) + distributed care (RPM/virtual) + connected data (interoperability).

For organisations focused on RCM, the implications are profound.

The vendor you pick must offer more than traditional claim‑submission or EHR modules. Moreover, it must enable the end‑to‑end flow – from patient eligibility and pre‑auth, through remote‑care touchpoints, to clean claims, faster payments and real‑time analytics – just like Flobotics ;-)

Before You Read | Useful Definitions

Here are 3 terms we’ll use throughout this post. If you’re not living in healthcare tech every day, they’re worth a quick skim:

  1. TEFCA — A U.S. federal framework to promote standardized health data exchange across all providers and vendors. If a platform is TEFCA-compliant, it likely plays well with others.

  2. ONC compliance — Refers to certification from the Office of the National Coordinator for Health IT. Indicates that a system meets federal health IT standards — especially around interoperability and patient access.

  3. VBC (Value-Based Care) — A reimbursement model focused on patient outcomes and cost-efficiency rather than service volume. Many platforms (like Innovaccer) are designed to support this shift.

  4. RPM (Remote Patient Monitoring) — The use of connected devices and apps to track patient vitals and health conditions outside of clinical settings. Often tied to chronic care programs and telehealth workflows.

Solutions | Top 20 Healthcare Softwares in 2025

Epic Logo

Epic Systems Corporation covers over 40% of the U.S. acute-care hospital market (2024 data). Used by over 350 health systems and 2,000+ hospitals. Known for stability, broad EHR+RCM integration, and regulatory alignment (e.g., TEFCA, ONC compliance).

Best fit:

Large hospital networks needing unified inpatient/outpatient workflows and mature interoperability.

Considerations:

High upfront implementation cost and long onboarding timelines.

AthenaHealth Logo Software

Athenahealth is a cloud-native platform with strong presence in outpatient and ambulatory settings.

In 2024, reported client productivity gains of up to 50% in charge lag and billing cycle metrics. MIPS Quality scores for practices using athenahealth are consistently above national average (2023: 78.74 vs 74.63).

Best fit: Mid-sized practices and multi-site outpatient groups prioritizing automation and quick ROI.

Considerations: Limited customization options for enterprise hospitals.

Medi Tech Logo

Meditech is a Longstanding EHR vendor serving community hospitals and mid-size health systems.

As of 2024, used in over 2,300 healthcare facilities. Expanse, its latest platform, emphasizes mobile-first and web-based usability.

Best fit: Community hospitals seeking modern EHR functionality without full Epic-level scale.

Considerations: Less depth in advanced analytics and AI tooling.

eClinicalWork logo

eClinicalWorks is one of the most widely adopted outpatient EHRs, especially among independent physician groups.

As of 2025, claims 180,000+ providers and over 850,000 medical professionals on the platform.

Best fit: Small to mid-sized clinics needing reliable EHR + billing integration.

Considerations: Past scrutiny on data interoperability and customer support.

NextGen Logo

NextGen Healthcare is a company focused on specialty-driven practices.

They offer tailored modules for orthopedics, behavioral health, OBGYN, and more. Publicly traded until 2023 acquisition by Thoma Bravo.

Best fit: Specialty practices with unique documentation and workflow needs.
Considerations: Less suitable for general-purpose hospitals.

Tebra Healtcare Platform Logo Image

Tebra, previously known as Kareo, is a company that targets small practices and medical billing companies.

They’re known for affordability, ease of use, and integrated billing. Now merged with PatientPop under the Tebra brand.

Best fit: Solo and small group practices aiming for all-in-one billing + charting platform.
Considerations: Limited configurability for complex use cases.

Greenway Health Healthcare Solution Logo

Green Health EMR is a practice management vendor serving 50,000+ providers.

Focuses on integrated RCM and care coordination. Noted for customer support turnaround improvement in 2024.

Best fit: Mid-sized practices needing end-to-end support from scheduling to collections.
Considerations: Slower release cycle on new features compared to cloud-native rivals.

AdvancedMD

AdvancedMD is a SaaS platform offering EHR, PM, billing, and telehealth. Part of Global Payments Inc. system. Supports independent practices with multi-location tools.
Best fit: Practices needing scalable support for virtual care and multi-site operations.
Considerations: More business-facing than deeply clinical in interface.

ModMed

ModMed (Modernizing Medicine) is a specialty-specific EHR with prebuilt templates and touch-based input. Used in dermatology, ophthalmology, and orthopedics. In 2023, ranked #1 for ambulatory specialty EHRs by Black Book.
Best fit: Specialists seeking out-of-the-box content and fast charting.
Considerations: Narrower applicability outside targeted specialties.

Praxis EMR logo image

Praxis EMR is a template-free, AI-driven EMR focused on physician note automation. Users report improved documentation speed and accuracy. Operates outside Meaningful Use certification.

Best fit: Independent physicians prioritizing documentation quality and speed.
Considerations: Non-traditional interface with steep learning curve.

Altera Digital Health Logo

Altera Digital Health (prev. Allscripts) – owned currently by Harris Computer, offers Sunrise platform for hospitals and TouchWorks for large practices. Interoperability features strengthened post-acquisition.

Best fit: Health systems needing modular platform options and long-term vendor stability.
Considerations: Slower innovation cycle compared to cloud-native platforms.

Innovaccer Logo Image

Innovaccer is a data platform used by 100+ health systems to unify clinical and claims data. Powers population health and analytics initiatives. Focused on value-based care enablement.
Best fit: Organizations prioritizing data integration, care coordination, and VBC contracts.
Considerations: Requires strong IT capacity to implement and maintain.

Careviso Logo Image

Careviso provides real-time benefits verification, cost estimation, and prior-authorization management through its seeQer platform. Used by over 200,000 providers, it claims over 2 million prior-auths processed and 300,000+ admin hours saved annually.

Best fit: Providers managing high volumes of insurance verifications, patient estimates, and prior-auth workflows.
Considerations: Works as an add-on; requires integration with existing EHR/RCM stack.

Kyruus Health Revspring Logo

Kyruus Health is a platform for provider search, scheduling, and patient access. Deployed in large health systems like Mass General Brigham. Supports digital front door strategies.
Best fit: Health systems aiming to streamline patient access and scheduling across departments.
Considerations: Integrates best with large multi-specialty systems.

Phreesia Software Logo

Phreesia is a patient intake and engagement software used by over 3,000 practices. Offers digital forms, mobile check-in, and payment tools. Publicly traded under ticker PHR.

Best fit: Practices looking to digitize front-desk workflows and increase collections.
Considerations: ROI strongest with medium-to-high patient volumes.

qure4u logo

Qure4u is a patient engagement platform offering remote monitoring, telehealth, and care plans. Integrated with major EHRs. Focused on extending care beyond the visit.
Best fit: Organizations expanding digital health and RPM initiatives.
Considerations: Best results when combined with robust clinical workflows.

Merative Logo IBM

Merative (prev. IBM Watson Health) offers clinical decision support, analytics, and imaging tools. Used in payer and provider orgs.
Best fit: Enterprises requiring mature analytics and compliance-ready data tools.
Considerations: Positioned more as enterprise data platform than EHR/RCM tool.

yosi-logo

Yosi Health is a check-in and pre-registration platform used by multi-location outpatient groups. Offers insurance verification and mobile intake. Used by CityMD and other urgent care providers.
Best fit: High-volume outpatient groups prioritizing speed and throughput.
Considerations: ROI depends on scale and check-in friction points.

SAS Healthcare Logo

SAS Healthcare Analytics provides predictive modeling and fraud detection tools. Used by CMS and large payers for analytics and audit functions.
Best fit: Payers and health systems investing in advanced analytics or risk adjustment.
Considerations: High expertise needed to build and manage models.

Optum Analytics Logo

Optum Analytics is a part of UnitedHealth Group. They offer data warehousing, performance metrics, and quality tracking. Their solution is commonly used in population health.
Best fit: Large systems engaged in payer-provider collaboration or value-based contracts.
Considerations: Deep ties to Optum ecosystem may limit vendor neutrality.

salesforce logo

Salesforce Health Cloud is a CRM-style platform for patient engagement, care coordination, and call centers. Used in payer/provider hybrid settings.
Best fit: Organizations with large call centers or care teams needing CRM + care tracking.
Considerations: Not an EHR replacement; best used alongside core systems.

Summary | Which Solutions To Choose?

Software alone won’t unclog your revenue streams. But the right stack—aligned with your workflows, built for your scale, and powered by agentic AI—can.

If you’re still relying on manual processes, you’re leaking revenue. If your EHR feels like a cost center, not a growth tool, it’s time to rethink. And if you’re not automating denials, pre-auths, and eligibility by now… you’re falling behind.

Time is revenue. Don’t lose either.

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